Effects of Methylsulfonylmethane on Hemodynamics and Oxidative Stress in
Monocrotaline-Induced Pulmonary Hypertensive Rats
Pharmacol Sci. 2012;2012:507278. doi: 10.1155/2012/507278. Epub 2012 Oct
Sadollah; Najafi, Moslem; Hamzeiy, Hossein; Maleki-Dizaji, Nasrin; Pezeshkian,
Masoud; Sadeghi-Bazargani, Homayon; Darabi, Masoud; Mostafalou, Sara; Bohlooli,
Shahab; Garjani, Alireza
(MSM) is naturally occurring organic sulfur that is known as a potent
antioxidant/anti-inflammatory compound. The aim of this study was to investigate
the effect of MSM on hemodynamics functions and oxidative stress in rats with
monocrotaline- (MCT-) induced pulmonary arterial hypertension (PAH). Wistar rats
were randomly assigned to 38-days treatment. MSM was administered to rats at
100, 200, and 400 mg/kg/day doses 10 days before a single dose of 60 mg/kg, IP,
MCT. Hemodynamics of ventricles were determined by Powerlab AD instrument. Blood
samples were obtained to evaluate changes in the antioxidative system including
activities of catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase
(GPx), and the level of reduced glutathione (GSH) and malondialdehyde (MDA).
Improvements in cardiopulmonary hemodynamics were observed in the MSM-treated
pulmonary arterial hypertensive rats, with a significant reduction in right
ventricular systolic pressure (RSVP) and an increase in the mean arterial
pressure (MAP). The values of CAT, SOD, GSH-px activities, and GSH were
significantly lower in MCT-induced PAH (P < 0.01), but they were recovered to
control levels of MSM-treated groups. Our present results suggest that long-term
administration of the MSM attenuates MCT-induced PAH in rats through modulation
of oxidative stress and antioxidant defense.
이 논문은 폐동맥 고혈압에 걸린 쥐가 MSM을 처리하였을 때 어떤 효과가 있나 알아보는 실험에 대한 결과입니다.
결론은 혈행개선이 되었다네요. 그래서 폐동맥 고혈압을 경감시켰다고 합니다.
쥐에게 화학물질로 폐동맥 고혈합을 유도시켰다는데 사람들 때문에 쥐가 이래저래 고생이네요.
MSM 덕에 졸지에 폐동맥고혈압이 생긴 쥐가 MSM으로 괜찮지길 바래봅니다. ^^
google에서 제목으로 검색을 하시면 논문 내용이 나옵니다. 혈행관련 논문으로 번역보기로 보시면 어떤 내용인지 보실 수 있습니다.
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