Abstract
The results from several studies examining the effects of DMSO on autoimmune
phenomena have been inconclusive, possibly because of differences in
experimental models, treatment regimens and doses employed. In the present
investigation, autoimmune strain MRL/lpr, C3H/lpr, and male BXSB
mice were placed on a continuous treatment regimen with 3% DMSO or 3%
DMSO2 in the drinking water, ad libitum, commencing at 1 to 2
months of age, before spontaneous disease development could be detected. This
represented doses of 8–10 g/kg/day of DMSO and 6–8 g/kg/day of DMSO2.
Both compounds were observed to extend the mean life span of MRL/lpr mice
from 5 1/2 months to over 10 months of age. All strains showed decreased
antinuclear antibody responses and significant diminution of lymphadenopathy,
splenomegaly, and anemia development. Serum IgG levels and spleen IgM antibody
plaque formation, however, did not differ from control values. There was no
indication of involvement of systemic immunosuppressive or antiproliferative
effects, and treated animals were observed to remain healthy and vigorous with
no signs of toxicity. These results demonstrate that high doses of both DMSO and
its major in vivo metabolite, DMSO2, provide significant
protection against the development of murine autoimmune lymphoproliferative
disease. Possible mechanisms of protection are discussed.
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